El antagonista del receptor H2 de la histamina, cimetidina, que es un inhibidor de múltiples isoenzimas CYP, incluyendo CYP3A4 y CYP2C19, minimize el aclaramiento del diazepam y del diazepam desmetilado del 40% al 50%. El efecto no es diferente tras un día de tratamiento o tras tratamiento crónico con cimetidina y resulta en una mayor exposición y en una semivida de eliminación prolongada de diazepam y de su principal metabolito tras una dosis única y a unas concentraciones en estado estacionario aumentadas tras múltiples dosis de diazepam.
El fármaco se metaboliza casi por completo y solo se elimina cantidades insignificantes de diazepam inalterado por la orina. El metabolito principal en orina es oxazepam-glucurónido.
Es posible que la somnolencia o el mareo puedan prolongarse durante más tiempo en los adultos mayores. Tenga especial cuidado y evite sufrir caídas o herirse accidentalmente.
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Lorazepam Hexal one mg Manufacturer es medicamento ansiolítico y esta indicado para tratar la ansiedad. Pertenece a una clase de medicamentos llamados benzodiacepinas, los cuales actúan en el sistema nervioso central.
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El Alcoholic beverages ralentiza la semivida de eliminación de los metabolitos de la Doxiciclina y puede provocar reacciones adversas. Debe evitarse el alcohol durante el tratamiento.
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El tratamiento para el insomnio debería comenzar evaluando los posibles problemas subyacentes, acudiendo después a terapias cognitivas conductuales y de autoayuda.